Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

Tsukasa Okiyoneda, Hervé Barrière, Miklós Bagdány, +5

Science

Protein SecretionMolecular BiologyCytoskeletonNonnative CftrProtein Refolding +20

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Tsukasa Okiyoneda, Guido Veit, Johanna F. Dekkers, +10

Nature Chemical Biology

Protein FoldingMechanism-based Corrector CombinationMolecular BiologyFoldable Structure

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

Wael M. Rabeh, Florian Bossard, Haijin Xu, +9

Cell

PhysicsProtein FoldingNatural SciencesApplied PhysicsMolecular Biology +3

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

Guido Veit, Radu G. Avramescu, Doranda Perdomo, +10

Science Translational Medicine

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Guido Veit, Haijin Xu, Elise Dréano, +19

Nature Medicine

Gene TherapiesStructure-guided Combination TherapyMolecular BiologyMutant CftrsNovel Therapy +1

Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells

György Panyi, György Vámosi, Zsolt Bacsó, +6

Proceedings of the National Academy of Sciences

ImmunologyImmunologic MechanismAntigen ProcessingImmunotherapyCellular Physiology +16

Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes

György Panyi, Miklós Bagdány, Andrea Bodnár, +8

Proceedings of the National Academy of Sciences

Lateral OrganizationImmunologyCellular PhysiologyElectron MicroscopyHyperpolarization (Biology) +15

Revisiting the Role of Cystic Fibrosis Transmembrane Conductance Regulator and Counterion Permeability in the pH Regulation of Endocytic Organelles

Hervé Barrière, Miklós Bagdány, Florian Bossard, +5

Molecular Biology of the Cell

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Miklós Bagdány, Guido Veit, Ryosuke Fukuda, +14

Nature Communications

Anuroctoxin, a New Scorpion Toxin of the α-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes

Miklós Bagdány, César V.F. Batista, Norma A. Valdez‐Cruz, +7

Molecular Pharmacology