Radu G. Avramescu

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

Radu G. Avramescu, Annette Chiang, Scott A. Houck et al. · Molecular Biology of the Cell · 2016 · 582 citations · Full text

Pathology, Combinatorial Pharmacotherapy, Synaptic Signaling +28

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

Guido Veit, Radu G. Avramescu, Doranda Perdomo et al. · Science Translational Medicine · 2014 · 283 citations · Full text

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Guido Veit, Haijin Xu, Elise Dréano et al. · Nature Medicine · 2018 · 138 citations · Full text

Gene Therapies, Structure-guided Combination Therapy, Molecular Biology +3

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

Peter M. Haggie, Puay‐Wah Phuan, Joseph‐Anthony Tan et al. · Journal of Biological Chemistry · 2016 · 90 citations · Full text

Signal Transduction, Molecular Physiology, Potentiators Rescue Function +11

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Miklós Bagdány, Guido Veit, Ryosuke Fukuda et al. · Nature Communications · 2017 · 69 citations · Full text