Dasatinib inhibits the secretion of TNF-α following TLR stimulation in vitro and in vivo

Shock and Tissue Injury Induced by Recombinant Human Cachectin

Kevin J. Tracey, Bruce Beutler, Stephen F. Lowry et al. · Science · 1986 · 2.6K citations

Veterinary Medicine, Immunology, Physiology +17

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Kevin J. Tracey, Yuman Fong, David Hesse et al. · Nature · 1987 · 2.5K citations

Veterinary Medicine, Immunology, Infectious Diseases +16

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Joachim Rothe, Werner Lesslauer, Hansruedi Lötscher et al. · Nature · 1993 · 1.3K citations

Life Sciences, Immunology, Microbiology +12

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

Charles J. Fisher, Jan M. Agosti, Steven M. Opal et al. · New England Journal of Medicine · 1996 · 1.3K citations

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Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

Manolis Pasparakis, Lena Alexopoulou, Vasso Episkopou et al. · The Journal of Experimental Medicine · 1996 · 1.2K citations · Full text

Life Sciences, Immunology, Pathology +15