Concepedia

cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics

Karen S. Lyle, J.H. Raaijmakers, Wytse Bruinsma, Johannes L. Bos, Johan de Rooij

Cellular Signalling · 2008 · 57 citations · 41 references

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References

41

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Johan de Rooij, Fried Zwartkruis, Mark H. G. Verheijen et al. · Nature · 1998 · 2K citations

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

M. G. P. Stoker, Ermanno Gherardi, M. Benjamin Perryman et al. · Nature · 1987 · 1.3K citations

, , +16

TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Hidenori Kasai, Jeremy Allen, Roger M. Mason et al. · Respiratory Research · 2005 · 742 citations · Full text

, , +15

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Jorrit M. Enserink, Anne Elisabeth Christensen, Johan de Rooij et al. · Nature Cell Biology · 2002 · 696 citations

, , +10

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

Ronen Zaidel‐Bar, Christoph Ballestrem, Zvi Kam et al. · Journal of Cell Science · 2003 · 668 citations

, , +17