Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial Cells - Concepedia

Concepedia

Publication | Closed Access

Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial Cells

50

Citations

26

References

2015

Year

Takuro Miyazaki, Yoshitaka Taketomi, Yuta Saito, Tomohiko Hosono, Xiao‐Feng Lei, Joo‐ri Kim‐Kaneyama, Satoru Arata, Haruo Takahashi, Makoto Murakami, Akira Miyazaki

Circulation Research

Abstract

Loss of CAST in angiogenic ECs facilitates μ-calpain-induced SOCS3 degradation, which amplifies pathological angiogenesis through interleukin-6/STAT3/VEGF-C axis.

References

	Year	Citations

Page 1