Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

Masanobu Oshima, Joseph Dinchuk, Stacia Kargman et al. · Cell · 1996 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Genetics +16

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

Brendan McAdam, Francesca Catella-Lawson, Issam A. Mardini et al. · Proceedings of the National Academy of Sciences · 1999 · 1.3K citations

Medicine, Pharmacology, Pharmacotherapy +13

Coxibs and Cardiovascular Disease

Garret A. FitzGerald · New England Journal of Medicine · 2004 · 896 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

Raymond C. Harris, J A McKanna, Youichi Akai et al. · Journal of Clinical Investigation · 1994 · 859 citations · Full text

Life Sciences, Biochemistry, Physiology +14

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

James N. Topper, Jiexing Cai, D Falb et al. · Proceedings of the National Academy of Sciences · 1996 · 840 citations

Life Sciences, Physiology, Biomechanics +14