James N. Topper

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

Hidetoshi Hayashi, Shirin Abdollah, Yubin Qiu et al. · Cell · 1997 · 1.3K citations · Full text

Signal Transduction, Immunology, Tgfβ Receptor +5

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

James N. Topper, Jiexing Cai, D Falb et al. · Proceedings of the National Academy of Sciences · 1996 · 838 citations · Full text

Turbulent Shear Stress, Vascular Disease, Engineering +21

Biomechanical activation: an emerging paradigm in endothelial adhesion biology.

Michael A. Gimbrone, Tobi Nagel, James N. Topper · Journal of Clinical Investigation · 1997 · 346 citations · Full text

Mechanobiology, Engineering, Vascular Adaptation +10

Vascular <i>MAD</i> s: Two novel <i>MAD</i> -related genes selectively inducible by flow in human vascular endothelium

James N. Topper, Jiexing Cai, Yubin Qiu et al. · Proceedings of the National Academy of Sciences · 1997 · 323 citations · Full text

Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements

Robert P. Fisher, James N. Topper, David A. Clayton · Cell · 1987 · 254 citations

Transcriptional Regulation, Mitochondrial Biogenesis, Medicine +11