Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

TLDR

Dietary restriction from early life slows aging, extends lifespan, and reduces many spontaneous cancers in rodents, but its impact when initiated in middle age is unclear. The study restricted food intake of 12‑ to 13‑month‑old mice from two long‑lived strains using nutrient‑enriched diets that provide undernutrition without malnutrition. Restricted feeding increased mean and maximum survival by 10–20 % and reduced spontaneous lymphoma incidence. No other information provided.

Abstract

Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without malnutrition." " The mice on the restricted diet averaged 10 to 20 percent increases in mean and maximum survival times compared to the control mice. Spontaneous lymphoma was inhibited by the food restriction.