TNF-α acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient—Effects on leptin and insulin signaling pathways

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

David Murray, Lisa Choy, Bruce M. Spiegelman · Proceedings of the National Academy of Sciences · 1994 · 1.2K citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

Cláudio Teodoro de Souza, Eliana P. Araújo, Silvana Bordin et al. · Endocrinology · 2005 · 1.2K citations · Full text

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Measurement of VO2, VCO2, and evaporative water loss with a flow-through mask

Philip C. Withers · Journal of Applied Physiology · 1977 · 869 citations

Life Sciences, Physiology, Zoology +17

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Jane K. Howard, Belinda J. Cave, Laura Oksanen et al. · Nature Medicine · 2004 · 491 citations

Life Sciences, Endocrinology, Physiology +14

SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

Brice Emanuelli, Pascal Peraldi, Chantal Filloux et al. · Journal of Biological Chemistry · 2001 · 446 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16