St. John’s Wort Modulates the Toxicities and Pharmacokinetics of CPT-11 (Irinotecan) in Rats

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

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Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Matthew R. Redinbo, Lance Stewart, Peter Kühn et al. · Science · 1998 · 878 citations

Life Sciences, Biochemistry, Molecular Biology +13

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicine, Oncology, Pharmacology +13

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

Ron H.J. Mathijssen, R J van Alphen, Jaco J. Verweij et al. · PubMed · 2001 · 752 citations · Full text

Medicine, Oncology, Pharmacology +17

A Model for the Mechanism of Human Topoisomerase I

Lance Stewart, Matthew R. Redinbo, Xiayang Qiu et al. · Science · 1998 · 703 citations

Life Sciences, Biochemistry, Molecular Biology +14