Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum

Fu-Ming Zhou, Yong Liang, John A. Dani · Nature Neuroscience · 2001 · 600 citations

Life Sciences, Neurobiology, Neuroscience +14

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Thomas Lang, Kathrin Klein, Joachim E. Fischer et al. · Pharmacogenetics · 2001 · 569 citations

Medicine, Genetics, Molecular Genetics +17

A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

E.S. Messina, Rachel F. Tyndale, Edward M. Sellers · Journal of Pharmacology and Experimental Therapeutics · 1997 · 452 citations

Medicine, Biochemistry, Pharmacology +17

CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants

L M Hesse, Karthik Venkatakrishnan, Michael H. Court et al. · Drug Metabolism and Disposition · 2000 · 399 citations

Medicine, Biochemistry, Pharmacology +17

Morphological Alterations in Hippocampus After Long-Term Alcohol Consumption in Mice

Joseph N. Riley, Don W. Walker · Science · 1978 · 290 citations

Life Sciences, Neurobiology, Neuroscience +10