A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

Daily intake of nicotine during cigarette smoking

Neal L. Benowitz, Peyton Jacob · Clinical Pharmacology & Therapeutics · 1984 · 503 citations

Medicine, Pharmacokinetics, Pharmacology +11

Interindividual variability in the metabolism and cardiovascular effects of nicotine in man.

Neal L. Benowitz, P. Jacob, R T Jones et al. · Journal of Pharmacology and Experimental Therapeutics · 1982 · 453 citations

Pharmacy, Pharmacology, Physiology +13

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

Leif Bertilsson, Ya‐Qing Lou, Yun-Long Du et al. · Clinical Pharmacology & Therapeutics · 1992 · 403 citations

Pharmacy, Pharmacology, Toxicology +10

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

Shigeru Yamano, Jun Tatsuno, Frank J. Gonzalez · Biochemistry · 1990 · 384 citations

Medicine, Biochemistry, Pharmacology +8

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

R. Ayesh, Jeffrey R. Idle, James Ritchie et al. · Nature · 1984 · 383 citations

Medicine, Biochemistry, Oncology +14