Long-term expression of human alpha1-antitrypsin gene in mouse liver achieved by intravenous administration of plasmid DNA using a hydrodynamics-based procedure

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

F Liu, Young Song, D Liu · Gene Therapy · 1999 · 1.7K citations

Life Sciences, Biotechnology, Molecular Biology +15

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

Yang Yang, Frederick A. Nunes, Klára Berencsi et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Immunology, Molecular Biology +15

High Levels of Foreign Gene Expression in Hepatocytes after Tail Vein Injections of Naked Plasmid DNA

G Zhang, Vladimir G. Budker, Jon A. Wolff · Human Gene Therapy · 1999 · 950 citations

Life Sciences, Biotechnology, Molecular Biology +14

Long-term persistence of plasmid DNA and foreign gone expression in mouse muscle

Jon A. Wolff, James J. Ludtke, Gyula Acsádi et al. · Human Molecular Genetics · 1992 · 739 citations

Life Sciences, Biotechnology, Genetics +16

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

Gudrun Schiedner, Núria Morral, Robin J. Parks et al. · Nature Genetics · 1998 · 646 citations

Life Sciences, Biotechnology, Molecular Biology +16