Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

Gudrun Schiedner, Núria Morral, Robin J. Parks, +6

Nature Genetics

Vivo Gene ExpressionIn Vivo Gene TherapyNatural SciencesImmunologyGenetic Engineering +11

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases

Clare E. Thomas, Gudrun Schiedner, Stefan Kochanek, +2

Proceedings of the National Academy of Sciences

Viral PathogenesisImmunologyImmunotherapyNeuroinflammationInflammation +20

Adenovirus-mediated regulable target gene expression <i>in vivo</i>

Mark Burcin, Gudrun Schiedner, Stefan Kochanek, +2

Proceedings of the National Academy of Sciences

Signal TransductionProtein ExpressionSignaling PathwayTransgene ExpressionHormonal Receptor +11

High Doses of a Helper-Dependent Adenoviral Vector Yield Supraphysiological Levels of <i>α</i> ₁ -Antitrypsin with Negligible Toxicity

Núria Morral, Robin J. Parks, Heshan Zhou, +6

Human Gene Therapy

Efficient Transformation of Primary Human Amniocytes by E1 Functions of Ad5: Generation of New Cell Lines for Adenoviral Vector Production

Gudrun Schiedner, Sabine Hertel, Stefan Kochanek

Human Gene Therapy

Viral ReplicationPrimary Human AmniocytesSynthetic VirologyPrimary Human CellsCell Culture +17

Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors

Gudrun Schiedner, Sabine Hertel, Marion M. Johnston, +3

Molecular Therapy

Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

Marinee Chuah, Gudrun Schiedner, Lieven Thorrez, +9

Blood

High-Capacity “Gutless” Adenoviral Vectors

Gudrun Schiedner, Paula R. Clemens, Christoph Volpers, +1

Elsevier eBooks

Gene VectorBiomolecular EngineeringMolecular BiologyVirology

A Hemodynamic Response to Intravenous Adenovirus Vector Particles Is Caused by Systemic Kupffer Cell-Mediated Activation of Endothelial Cells

Gudrun Schiedner, Wilhelm Bloch, Sabine Hertel, +6

Human Gene Therapy

Endothelial CellsImmunologyViral PathogenesisCell DeathInnate Immunity +14

High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells

Yvonne Genzel, Thomas Vogel, Johannes Buck, +5

Vaccine

Suspension CellsEngineeringMedicineFlow CellVirology +6