PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

Hua Zhong, Kelly A. Chiles, David M. Feldser et al. · PubMed · 2000 · 1.5K citations

Cancer Biology, Tumor Biology, Tumor Angiogenesis +17

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

Elke Cario, Daniel K. Podolsky · Infection and Immunity · 2000 · 1.2K citations · Full text

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

Eric Huang, Zoltàn Arany, David M. Livingston et al. · Journal of Biological Chemistry · 1996 · 1.2K citations · Full text

Cellular Physiology, Redox Biology, Oxidative Stress +20

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

Tian Wang, Terrence Town, Lena Alexopoulou et al. · Nature Medicine · 2004 · 1.1K citations

Neurovirology, Medicine, Pathogenesis +10

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Kathrin S. Michelsen, Michelle Wong, Prediman K. Shah et al. · Proceedings of the National Academy of Sciences · 2004 · 1K citations · Full text

Vascular Disease, Innate Immune System, Immunology +17