Transgenic Induction of Vascular Endothelial Growth Factor-C Is Strongly Angiogenic in Mouse Embryos but Leads to Persistent Lymphatic Hyperplasia in Adult Tissues

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Peter Carmeliet, Valérie Ferreira, Georg Breier et al. · Nature · 1996 · 4.1K citations

Life Sciences, Developmental Biology, Genetics +14

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Napoleone Ferrara, Karen Carver-Moore, Helen Chen et al. · Nature · 1996 · 3.7K citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

Mihaela Skobe, Thomas Hawighorst, David G. Jackson et al. · Nature Medicine · 2001 · 1.7K citations

Medicine, Cancer Biology, Oncology +16

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

Arja Kaipainen, Jaana Korhonen, Tuija Mustonen et al. · Proceedings of the National Academy of Sciences · 1995 · 1.4K citations

Life Sciences, Developmental Biology, Molecular Biology +13

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

Marika J. Karkkainen, Paula Haiko, Kirsi Sainio et al. · Nature Immunology · 2003 · 1.4K citations

Life Sciences, Cell Biology, Developmental Biology +16