Concepedia

How Does Leflunomide Modulate the Immune Response in Rheumatoid Arthritis?

Robert I. Fox, Matthias Herrmann, Costakis Frangou, Geoffrey M. Wahl, Randall E. Morris, Bernhard J. Kirschbaum

BioDrugs · 1999 · 33 citations · 57 references

DOI

Concepts

References

57

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Pumin Zhang, J. Wade Harper, Stephen J. Elledge et al. · Cell · 1995 · 2.1K citations · Full text

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Aldo Di Leonardo, Steven P. Linke, Kristie Clarkin et al. · Genes & Development · 1994 · 1.2K citations · Full text

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p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

Carmé Caelles, Arno Helmberg, Michael Karin · Nature · 1994 · 847 citations

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Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial

Josef S Smolen, Joachim R. Kalden, David L. Scott et al. · The Lancet · 1999 · 773 citations

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