Transgenic mice with neuron-specific overexpression of HtrA2/Omi suggest a neuroprotective role for HtrA2/Omi

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva et al. · Nature · 1995 · 4K citations

Neurodegenerative Diseases, Early-onset Familial Alzheimer, Alzheimer's Disease +7

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

Ephrat Levy‐Lahad, Wilma Wasco, Parvoneh Poorkaj et al. · Science · 1995 · 2.6K citations

Alzheimer's Disease, Genetic Disorder, Genetics +12

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Robin Sherrington, Ekaterina Rogaeva, Georges Lévesque et al. · Nature · 1995 · 2.1K citations

Disease Heterogeneity, Alzheimer's Disease, Mendelian Disorder +10

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

Yasuyuki Suzuki, Yuzuru Imai, Hiroshi Nakayama et al. · Molecular Cell · 2001 · 1.1K citations · Full text

Mitophagy, Inducing Cell Death, Mitochondrial Function +11

A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein

Christoph Spiess, Alexandra Beil, Michael Ehrmann · Cell · 1999 · 757 citations · Full text

Protein Function, Biochemistry, Protein Assembly +9