Concepedia

Smac mimetics and innate immune stimuli synergize to promote tumor death

Shawn T. Beug, Vera A. Tang, Eric C. LaCasse, Herman H. Cheung, Caroline E. Beauregard, J Brun, Jeffrey P Nuyens, Nathalie Earl, Martine St-Jean, Janelle Holbrook,

Nature Biotechnology · 2014 · 133 citations · 33 references

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33

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson et al. · Cell · 2007 · 1.2K citations · Full text

, , +16

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

Mathieu J.M. Bertrand, Snezana Milutinovic, Kathleen M. Dickson et al. · Molecular Cell · 2008 · 1.1K citations

, , +13

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

James E. Vince, W. Wei‐Lynn Wong, Nufail Khan et al. · Cell · 2007 · 1.1K citations · Full text

, , +14

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

David F. Stojdl, Brian D. Lichty, Benjamin R. tenOever et al. · Cancer Cell · 2003 · 848 citations · Full text

, , +14

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

Li Lin, Ranny Mathew Thomas, Hidetaka Suzuki et al. · Science · 2004 · 658 citations

, , +17