High-performance liquid chromatographic assay with fluorescence detection for the evaluation of inhibitors against fatty acid amide hydrolase

Modulation of anxiety through blockade of anandamide hydrolysis

Satish Kathuria, Silvana Gaetani, Darren Fegley et al. · Nature Medicine · 2002 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +12

Chemical Characterization of a Family of Brain Lipids That Induce Sleep

Benjamin F. Cravatt, Oscar Prospéro‐García, Gary Siuzdak et al. · Science · 1995 · 619 citations

Life Sciences, Neurobiology, Neuroscience +15

Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation

Darren Fegley, Silvana Gaetani, Andrea Duranti et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 430 citations · Full text

Medicine, Neuroscience, Pharmacology +11

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

Donmienne Leung, Christophe Hardouin, Dale L. Boger et al. · Nature Biotechnology · 2003 · 385 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11

Cyclohexylcarbamic Acid 3‘- or 4‘-Substituted Biphenyl-3-yl Esters as Fatty Acid Amide Hydrolase Inhibitors:  Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling Studies

Marco Mor, Silvia Rivara, Alessio Lodola et al. · Journal of Medicinal Chemistry · 2004 · 274 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16