Christophe Hardouin

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

Donmienne Leung, Christophe Hardouin, Dale L. Boger et al. · Nature Biotechnology · 2003 · 385 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11

Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

Aron H. Lichtman, Donmienne Leung, Christopher C. Shelton et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 327 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Dale L. Boger, Hiroshi Miyauchi, Wu Du et al. · Journal of Medicinal Chemistry · 2004 · 213 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Fundamental Role of the Fostriecin Unsaturated Lactone and Implications for Selective Protein Phosphatase Inhibition

Suzanne B. Buck, Christophe Hardouin, Satoshi Ichikawa et al. · Journal of the American Chemical Society · 2003 · 114 citations

Life Sciences, Biochemistry, Pharmacology +15

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

Donmienne Leung, Wu Du, Christophe Hardouin et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 106 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17