Christophe Hardouin

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

Donmienne Leung, Christophe Hardouin, Dale L. Boger et al. · Nature Biotechnology · 2003 · 385 citations

Proteomic Technology, Complex Proteomes, Biochemistry +10

Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

Aron H. Lichtman, Donmienne Leung, Christopher C. Shelton et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 325 citations

Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Dale L. Boger, Hiroshi Miyauchi, Wu Du et al. · Journal of Medicinal Chemistry · 2004 · 213 citations · Full text

Pharmaceutical Science, Drug Target, Pain Medicine +21

Fundamental Role of the Fostriecin Unsaturated Lactone and Implications for Selective Protein Phosphatase Inhibition

Suzanne B. Buck, Christophe Hardouin, Satoshi Ichikawa et al. · Journal of the American Chemical Society · 2003 · 114 citations

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

Donmienne Leung, Wu Du, Christophe Hardouin et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 104 citations · Full text

Biochemistry, Natural Sciences, Medicine +11