Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

R. Clark Billinghurst, Leif Dahlberg, Mirela Ionescu et al. · Journal of Clinical Investigation · 1997 · 975 citations · Full text

Medicine, Orthopaedic Surgery, Pathology +14

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

Peter G. Mitchell, Holly A. Magna, Lucy Reeves et al. · Journal of Clinical Investigation · 1996 · 943 citations · Full text

Medicine, Pathology, Carcinogenesis +15

Biochemical Characterization of Human Collagenase-3

Vera Knäuper, Carlos López-Otı́n, Bryan Ronain Smith et al. · Journal of Biological Chemistry · 1996 · 879 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

Lisa A. Neuhold, Loran M. Killar, Weiguang Zhao et al. · Journal of Clinical Investigation · 2001 · 537 citations · Full text

Medicine, Pathobiology, Pathology +17

Role of interleukin‐1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage

Masahiko Kobayashi, Ginette R. Squires, Aisha Mousa et al. · Arthritis & Rheumatism · 2005 · 505 citations

Medicine, Immunology, Orthopaedic Surgery +17