IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE)

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Marina Cella, Doris Scheidegger, Kathrin Palmer-Lehmann et al. · The Journal of Experimental Medicine · 1996 · 2K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

Youhai Chen, Vijay K. Kuchroo, Jun-ichi Inobe et al. · Science · 1994 · 2K citations

Life Sciences, Immunology, Autoimmunity +16

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

Vijay K. Kuchroo, Mercy Prabhu Das, Julia A. Brown et al. · Cell · 1995 · 1.7K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

MF Neurath, Ivan J. Fuss, Brian L. Kelsall et al. · The Journal of Experimental Medicine · 1995 · 1.3K citations · Full text

Veterinary Medicine, Immunology, Pathology +17

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

Franz Koch, Ursula Stanzl, Patricia Jennewein et al. · The Journal of Experimental Medicine · 1996 · 930 citations · Full text

Life Sciences, Cell Biology, Immunology +17