Concepedia

Cd40l Signaling

CD40L Signaling is a costimulatory signaling pathway in which the CD40 ligand (CD40L) expressed on T cells binds to CD40 on antigen-presenting cells, thereby activating downstream immune responses essential for T-cell-dependent B-cell activation, dendritic cell maturation, and immunoglobulin class switching.

1.4K

Publications

102.3K

Citations

7.6K

Authors

1.6K

Institutions

Publications per year

2017–2026

135

Variants

Cd40 Ligand Signaling

Parents

Publications

1.4K

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

Stephen P. Schoenberger, René E. M. Toes, Ellen I. H. van der Voort et al. · Nature · 1998 · 2.6K citations

, , +15

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Marina Cella, Doris Scheidegger, Kathrin Palmer-Lehmann et al. · The Journal of Experimental Medicine · 1996 · 2K citations · Full text

, , +17

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

Gregory L. Beatty, E. Gabriela Chiorean, Matthew P. Fishman et al. · Science · 2011 · 1.6K citations

, , +17

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

Dagmar Breitfeld, Lars Ohl, Elisabeth Kremmer et al. · The Journal of Experimental Medicine · 2000 · 1.4K citations · Full text

, , +17

Molecular and biological characterization of a murine ligand for CD40

Richard J. Armitage, William C. Fanslow, L Strockbine et al. · Nature · 1992 · 1K citations

, , +13

1–5 of 1.4K

Authors

7.6K

  1. WC
    William C. Fanslow

    Research & Development Corporation, Canada

    22 publications · 3.2K citations

    21

    h-index

  2. PL
    Peter Libby

    Brigham and Women's Hospital, United States

    19 publications · 3.9K citations

    19

    h-index

  3. RJ
    Randolph J. Noelle

    Dartmouth College, United States

    18 publications · 2.6K citations

    17

    h-index

  4. US
    Uwe Schönbeck

    Brigham and Women's Hospital, United States

    16 publications · 3.5K citations

    16

    h-index

  5. CV
    Cees van Kooten

    Leiden University Medical Center, Netherlands

    16 publications · 1.6K citations

    15

    h-index

1–5 of 7.6K

Institutions

1.6K

  1. Harvard University

    Cambridge, United States

    33 h-index

    216 publications

    19K citations

  2. National Institutes of Health

    Bethesda, United States

    32 h-index

    159 publications

    13.5K citations

  3. Inserm

    Paris, France

    30 h-index

    252 publications

    26.5K citations

  4. Brigham and Women's Hospital

    Boston, United States

    26 h-index

    150 publications

    27K citations

  5. Yale University

    New Haven, United States

    23 h-index

    101 publications

    15.7K citations

  6. National Cancer Institute

    Bethesda, United States

    22 h-index

    81 publications

    6.4K citations

  7. Research & Development Corporation

    St. John's, Canada

    19 h-index

    73 publications

    11.1K citations

  8. University of Pennsylvania

    Philadelphia, United States

    19 h-index

    80 publications

    17.5K citations

1–8 of 1.6K

Venues

  1. The Journal of Immunology

    JI · 201 publications · 17.1K citations

    78

    h-index

  2. Blood

    67 publications · 6.5K citations

    47

    h-index

  3. European Journal of Immunology

    EJI · 77 publications · 5.1K citations

    43

    h-index

  4. PubMed

    Repository · 49 publications · 2.5K citations

    31

    h-index

  5. The Journal of Experimental Medicine

    27 publications · 8.8K citations

    26

    h-index

1–5