Concepedia

Quality by design: Impact of formulation variables and their interactions on quality attributes of a lyophilized monoclonal antibody

David Awotwe‐Otoo, Cyrus Agarabi, Geoffrey Wu, Elizabeth Casey, Erik K. Read, Scott Lute, Kurt Brorson, Mansoor A. Khan, Rakhi B. Shah

International Journal of Pharmaceutics · 2012 · 90 citations · 22 references

DOI

Concepts

References

22

Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 451 citations · Full text

, , +17

Antibody-based therapeutics to watch in 2011

Janice M. Reichert · mAbs · 2011 · 234 citations · Full text

, , +17

Inverse Relationship of Protein Concentration and Aggregation

Michael J. Treuheit, Andrew A. Kosky, David N. Brems · Pharmaceutical Research · 2002 · 209 citations

, , +13

Effects of Solution Conditions, Processing Parameters, and Container Materials on Aggregation of a Monoclonal Antibody during Freeze-Thawing

Lisa A. Kueltzo, Wen‐na Wang, Theodore W. Randolph et al. · Journal of Pharmaceutical Sciences · 2007 · 199 citations

, , +17

Effect of Moisture on the Stability of a Lyophilized Humanized Monoclonal Antibody Formulation

E. D. Breen, J. G. Curley, David E. Overcashier et al. · Pharmaceutical Research · 2001 · 193 citations

, , +11