Concepedia

Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of IκB-α

Hye‐Sun Shin, Seong‐Il Kang, Seon‐A Yoon, Hee‐Chul Ko, Se‐Jae Kim

Bioscience Biotechnology and Biochemistry · 2012 · 52 citations · 15 references

DOI

Concepts

Abstract

Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

References

15

NF-κB: Ten Years After

Patrick A. Baeuerle, David Baltimore · Cell · 1996 · 3K citations · Full text

, , +7

PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit

Takashi Tanaka, Michael J. Grusby, Tsuneyasu Kaisho · Nature Immunology · 2007 · 325 citations

, , +9

Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones

Shiming Li, Min‐Hsiung Pan, Chih‐Yu Lo et al. · Journal of Functional Foods · 2008 · 257 citations · Full text

, , +13

Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

D. Bharat Reddy, Pallu Reddanna · Biochemical and Biophysical Research Communications · 2009 · 171 citations

, , +12

6-Gingerol inhibits ROS and iNOS through the suppression of PKC-α and NF-κB pathways in lipopolysaccharide-stimulated mouse macrophages

Tzung-Yan Lee, Ko-Chen Lee, Shih-Yuan Chen et al. · Biochemical and Biophysical Research Communications · 2009 · 157 citations

, , +11