Organic Letters · 2012 · 57 citations · 28 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryChemical Library DesignCombinatorial SynthesisDiversity-oriented SynthesisHeterocycle SynthesisHeterocyclic ChemistryRetrosynthetic AnalysisAssembly ProcedureDiversity-oriented Heterocycle SynthesisHeterocyclic Medicinal ChemistryMacrocycle DiversificationMacrocyclic Library ConstructionMulticomponent Heterocycle Synthesis
An efficient multicomponent-based methodology providing a new entry into a medicinally important complex heterocyclic core is presented. The strategy is very general and able to endow target compounds with the highest possible number of diversity points. Notably, four new chemical bonds and two aromatic rings are formed in a one-pot fashion.
28
Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way
Hugues Bienaymé, Chris Hulme, G. ODDON et al. · Chemistry - A European Journal · 2000 · 1.1K citations · Full text