Concepedia

Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60)

Jiřina Vávrová, Lenka Zárybnická, Emı́lie Lukášová, Martina Řezáčová, Eva Novotná, Zuzana Šinkorová, Aleš Tichý, Jaroslav Pejchal, Kamila Ďurišová

Radiation and Environmental Biophysics · 2013 · 33 citations · 20 references

DOI

Concepts

References

20

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist, Michael B. Kastan · Nature · 2003 · 3.4K citations

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Aldo Di Leonardo, Steven P. Linke, Kristie Clarkin et al. · Genes & Development · 1994 · 1.2K citations · Full text

, , +17

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

Jann N. Sarkaria, Ericka C. Busby, Randal S. Tibbetts et al. · PubMed · 1999 · 1K citations

, , +16

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

A. Malcolm R. Taylor, D.G. Harnden, C.F. Arlett et al. · Nature · 1975 · 989 citations

, , +16

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.

G.J. Brunn, Josie M. Williams, Candace J. Sabers et al. · The EMBO Journal · 1996 · 723 citations · Full text

, , +14