Loop-Sequence Features and Stability Determinants in Antibody Variable Domains by High-Throughput Experiments

High-resolution mapping of protein sequence-function relationships

Douglas M. Fowler, Carlos L. Araya, Sarel J. Fleishman et al. · Nature Methods · 2010 · 612 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Crystal structure of a <i>Staphylococcus aureus</i> protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity

Marc Graille, E.A. Stura, Adam L. Corper et al. · Proceedings of the National Academy of Sciences · 2000 · 523 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

A New Clustering of Antibody CDR Loop Conformations

Benjamin North, Andreas Lehmann, Roland L. Dunbrack · Journal of Molecular Biology · 2010 · 402 citations

Life Sciences, Immunology, Molecular Biology +14

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

Timothy A. Whitehead, Aaron Chevalier, Yifan Song et al. · Nature Biotechnology · 2012 · 386 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Critical role of beta-hairpin formation in protein G folding.

Erika L. McCallister, Eric J. Alm, David Baker · Nature Structural Biology · 2000 · 374 citations

Life Sciences, Biochemistry, Molecular Biology +16