Concepedia

Antibody Loop Engineering

Antibody Loop Engineering is a computational and experimental methodology within antibody specificity engineering that involves the targeted modification of the complementarity-determining region loops in an antibody's variable domain to alter antigen-binding affinity and selectivity.

20

Publications

1K

Citations

150

Authors

46

Institutions

Publications per year

2017–2026

5

Parents

Publications

20

Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies

Dirk Saerens, Mireille Pellis, Remy Loris et al. · Journal of Molecular Biology · 2005 · 254 citations

, , +16

Design and Synthesis of a Mimetic from an Antibody Complementarity-Determining Region

H. Uri Saragovi, Dennis Fitzpatrick, Apichaya Raktabutr et al. · Science · 1991 · 165 citations

, , +16

“Superhumanized” Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD28

Philip Tan, David A. Mitchell, Timothy N. Buss et al. · The Journal of Immunology · 2002 · 98 citations

, , +17

An integrated approach to extreme thermostabilization and affinity maturation of an antibody

Audrey D. McConnell, V. Spasojevich, John L. Macomber et al. · Protein Engineering Design and Selection · 2012 · 51 citations · Full text

, , +16

Antibody binding loop insertions as diversity elements

Csaba Kiss, Hugh E. Fisher, Emanuele Pesavento et al. · Nucleic Acids Research · 2006 · 44 citations · Full text

, , +17

1–5 of 20

Authors

150

  1. HU
    H. Uri Saragovi

    McGill University, Canada

    1 publications · 165 citations

    1

    h-index

  2. MK
    Martin King

    MRC Mitochondrial Biology Unit, United Kingdom

    1 publications · 35 citations

    1

    h-index

  3. JF
    Jefferson Foote

    Fred Hutch Cancer Center, United States

    1 publications · 98 citations

    1

    h-index

  4. SB
    Stéphane Blésa

    Institut Pasteur, France

    1 publications · 30 citations

    1

    h-index

  5. HK
    Heide Kogelberg

    Northwick Park Hospital, United Kingdom

    1 publications · 30 citations

    1

    h-index

1–5 of 150

Institutions

46

  1. University of Washington

    Seattle, United States

    2 h-index

    7 publications

    230 citations

  2. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    4 publications

    359 citations

  3. Scripps Research Institute

    San Diego, United States

    1 h-index

    4 publications

    88 citations

  4. Technical University of Munich

    Munich, Germany

    1 h-index

    1 publications

    17 citations

  5. Technische Universität Darmstadt

    Darmstadt, Germany

    1 h-index

    1 publications

    17 citations

  6. UCB Pharma (Belgium)

    Brussels, Belgium

    1 h-index

    1 publications

    39 citations

  7. Ragon Institute of MGH, MIT and Harvard

    Cambridge, United States

    1 h-index

    1 publications

    22 citations

  8. International AIDS Vaccine Initiative

    New York, United States

    1 h-index

    4 publications

    88 citations

1–8 of 46

Venues

  1. Protein Engineering Design and Selection

    PEDS · 4 publications · 114 citations

    4

    h-index

  2. Journal of Molecular Biology

    JMB · 3 publications · 314 citations

    3

    h-index

  3. Structure

    2 publications · 62 citations

    2

    h-index

  4. 1

    h-index

  5. Scientific Reports

    1 publications · 39 citations

    1

    h-index

1–5