Concepedia

Variable Region Structure

Variable Region Structure is the antigen-binding domain of an immunoglobulin molecule that confers specificity through hypervariable loops within the N-terminal segments of heavy and light chains, distinguished from constant regions by its sequence diversity and role in molecular recognition.

342

Publications

25.4K

Citations

1.3K

Authors

429

Institutions

Publications per year

2017–2026

15

Variants

Variable Domain Structure

Parents

Publications

342

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

James S. Huston, Dennis J. Levinson, M Mudgett-Hunter et al. · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

, , +17

Canonical structures for the hypervariable regions of immunoglobulins

Cyrus Chothia, Arthur M. Lesk · Journal of Molecular Biology · 1987 · 1.4K citations

, , +14

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

Tai Te Wu, Elvin A. Kabat · The Journal of Experimental Medicine · 1970 · 1.3K citations · Full text

, , +17

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

E. Sally Ward, Detlef Güssow, Andrew D. Griffiths et al. · Nature · 1989 · 992 citations

, , +14

Structure of a V3-Containing HIV-1 gp120 Core

Chih-chin Huang, Min Tang, Mei-Yun Zhang et al. · Science · 2005 · 723 citations

, , +17

1–5 of 342

Authors

1.3K

  1. JD
    J. Donald Capra

    The University of Texas Southwestern Medical Center, United States

    12 publications · 779 citations

    12

    h-index

  2. WH
    William H. Konigsberg

    Yale University, United States

    7 publications · 219 citations

    7

    h-index

  3. EA
    Elvin A. Kabat

    Columbia University, United States

    7 publications · 1.8K citations

    7

    h-index

  4. JD
    J D Capra

    The University of Texas Southwestern Medical Center, United States

    6 publications · 229 citations

    6

    h-index

  5. MS
    M. Schiffer

    Argonne National Laboratory, United States

    6 publications · 192 citations

    6

    h-index

1–5 of 1.3K

Institutions

429

  1. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    13 h-index

    40 publications

    11K citations

  2. Harvard University

    Cambridge, United States

    11 h-index

    31 publications

    5.6K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    37 publications

    2.3K citations

  4. National Cancer Institute

    Bethesda, United States

    9 h-index

    33 publications

    10.2K citations

  5. New York University

    New York, United States

    8 h-index

    27 publications

    1.7K citations

  6. National Institutes of Health

    Bethesda, United States

    6 h-index

    16 publications

    1.7K citations

  7. Columbia University

    New York, United States

    6 h-index

    12 publications

    3.4K citations

  8. Institut Pasteur

    Paris, France

    6 h-index

    14 publications

    1.5K citations

1–8 of 429

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 46 publications · 4.4K citations

    34

    h-index

  2. The Journal of Immunology

    JI · 21 publications · 809 citations

    17

    h-index

  3. Molecular Immunology

    22 publications · 976 citations

    15

    h-index

  4. Journal of Biological Chemistry

    JBC · 15 publications · 969 citations

    14

    h-index

  5. Journal of Molecular Biology

    JMB · 14 publications · 2.9K citations

    14

    h-index

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