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2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors

Jiaqiang Cai, David Jonathan Bennett, Zoran Ranković, Maureen Dempster, Xavier Fradera, Jonathan Gillespie, Iain Cumming, William J.J. Finlay, Mark Baugh, Sylviane Boucharens,

Bioorganic & Medicinal Chemistry Letters · 2010 · 12 citations · 17 references

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17

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Anna K. Clark, Ping K. Yip, John Grist et al. · Proceedings of the National Academy of Sciences · 2007 · 481 citations · Full text

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Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity

Jean‐Pierre Falgueyret, Sylvie Desmarais, Renata M. Oballa et al. · Journal of Medicinal Chemistry · 2005 · 153 citations · Full text

, , +17

Novel Purine Nitrile Derived Inhibitors of the Cysteine Protease Cathepsin K

Eva Altmann, Sandra W. Cowan‐Jacob, Martin Missbach · Journal of Medicinal Chemistry · 2004 · 72 citations · Full text

, , +12

The identification of potent, selective, and bioavailable cathepsin S inhibitors

Jacques Yves Gauthier, W. Cameron Black, Isabelle Courchesne et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 58 citations · Full text

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Novel scaffold for cathepsin K inhibitors

Naoki Teno, Takahiro Miyake, Takeru Ehara et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · Full text

, , +14