Antioxidants and Redox Signaling · 2002 · 292 citations · 16 references
Life SciencesGeneticsMolecular BiologyAgingMolecular ToxicologyRedox BiochemistryAntioxidant DefenseCellular ToxicologyOxidative Damage To BiomoleculesOxidative StressOxidative Stress MechanismsReactive Oxygen SpeciesBone Marrow - Derived CellsLife Span ExtensionOxidative Stress AdaptationOxidative Stress ToxicityTelomerase Activity AssessmentTelomerase EnzymeTelomerase RegulationTransgenic Mice
Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.
16
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Enrica Migliaccio, Marco Giorgio, Simonetta Mele et al. · Nature · 1999 · 1.7K citations
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
K. Lenhard Rudolph, Sandy Chang, Han‐Woong Lee et al. · Cell · 1999 · 1.3K citations · Full text