Concepedia

Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis

Mervat H. El‐Hamamsy, Anthony W. Smith, Andrew S. Thompson, Michael D. Threadgill

Bioorganic & Medicinal Chemistry · 2007 · 61 citations · 41 references

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41

Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis

Koichi Takayama, J O Kilburn · Antimicrobial Agents and Chemotherapy · 1989 · 361 citations · Full text

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Recognition of the lipid intermediate for arabinogalactan/arabinomannan biosynthesis and its relation to the mode of action of ethambutol on mycobacteria.

Beata A. Wolucka, Michael McNeil, Edmond de Hoffmann et al. · Journal of Biological Chemistry · 1994 · 267 citations · Full text

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Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

Rongbao Li, Rachada Sirawaraporn, P. Chitnumsub et al. · Journal of Molecular Biology · 2000 · 205 citations

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Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Jay F. Davies, Tavner J. Delcamp, Neal J. Prendergast et al. · Biochemistry · 1990 · 179 citations

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Microbial oxidation of chloroaromatics in the enantiodivergent synthesis of pyrrolizidine alkaloids: trihydroxyheliotridanes

Tomáš Hudlický, Héctor Luna, John D. Price et al. · The Journal of Organic Chemistry · 1990 · 159 citations

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