Concepedia

Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization

Solomon D. Kattar, Laura Surdi, Anna A. Zabierek, Joey L. Methot, Richard E. Middleton, Bethany Hughes, Alexander A. Szewczak, William K. Dahlberg, Astrid M. Kral, Nicole Ozerova,

Bioorganic & Medicinal Chemistry Letters · 2008 · 28 citations · 10 references

DOIFull text

Open access

Concepts

References

10

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked <i>in vivo</i> antitumor activity against human tumors

Akiko Saito, Takashi Yamashita, Yukiyasu Mariko et al. · Proceedings of the National Academy of Sciences · 1999 · 696 citations · Full text

, , +13

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Alessandro Vannini, Cinzia Volpari, Gessica Filocamo et al. · Proceedings of the National Academy of Sciences · 2004 · 627 citations · Full text

, , +13

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

Victoria M. Richon, Yael Webb, R Merger et al. · Proceedings of the National Academy of Sciences · 1996 · 421 citations

, , +13

Linking the epigenetic ‘language’ of covalent histone modifications to cancer

Sandra B. Hake, Andrew Xiao, C. David Allis · British Journal of Cancer · 2004 · 387 citations · Full text

, , +17

Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives

Tsuneji Suzuki, Tomoyuki Ando, Katsutoshi Tsuchiya et al. · Journal of Medicinal Chemistry · 1999 · 291 citations · Full text

, , +9