Depletion of Securin Induces Senescence After Irradiation and Enhances Radiosensitivity in Human Cancer Cells Regardless of Functional p53 Expression

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.3K citations · Full text

A DNA damage checkpoint response in telomere-initiated senescence

Fabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace et al. · Nature · 2003 · 2.7K citations

Chromatin, Genome Instability, Dna Damage +7

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text

Aging, Cell Division, Medicine +3

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Christian Beauséjour · The EMBO Journal · 2003 · 1.4K citations · Full text

Developmental Biology, Anti-aging, Aging +8

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

Bey-Dih Chang, Eugenia V. Broude, Milos Dokmanovic et al. · PubMed · 1999 · 546 citations

Slp Markers, Pathology, Cell Proliferation +20