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Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists

Giancarlo Trani, Stuart M. Baddeley, Michael A. Briggs, Tsu Tshen Chuang, Nigel Deeks, Christopher N. Johnson, Abir A. Khazragi, Tania Mead, Andrew D. Medhurst, Peter H. Milner,

Bioorganic & Medicinal Chemistry Letters · 2008 · 23 citations · 6 references

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Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450

Charles L. Crespi, Vaughn P. Miller, Bruce W. Penman · Analytical Biochemistry · 1997 · 408 citations

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5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation—an effect sensitive to NMDA receptor antagonism

Madeleine V. King, Andrew J. Sleight, Marie L. Woolley et al. · Neuropharmacology · 2004 · 194 citations

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5-Chloro-<i>N</i>-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046):  A Potent, Selective, and Orally Bioavailable 5-HT<sub>6</sub> Receptor Antagonist

Steven M. Bromidge, Anthony M. Brown, Stephen E. Clarke et al. · Journal of Medicinal Chemistry · 1999 · 170 citations · Full text

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5-HT 6 receptor antagonists enhance retention of a water maze task in the rat

D F Rogers, J.J. Hagan · Psychopharmacology · 2001 · 152 citations

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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists

Mahmood Ahmed, Michael A. Briggs, Steven M. Bromidge et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 47 citations · Full text

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