Concepedia

Rational design of a Tn antigen mimic

Francisco Corzana, Jesús H. Busto, Filipa Marcelo, Marisa García de Luis, Juan Luis Asensio, Sonsoles Martín‐Santamaría, Yolanda Sáenz, Cármen Torres, Jesús Jiménez‐Barbero, Alberto Avenoza,

Chemical Communications · 2011 · 25 citations · 35 references

DOI

Concepts

Abstract

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.

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