Concepedia

Application of a High-Throughput Relative Chemical Stability Assay to Screen Therapeutic Protein Formulations by Assessment of Conformational Stability and Correlation to Aggregation Propensity

Joseph M. Rizzo, Shuai Shi, Yunsong Li, Andrew Semple, Jessica J. Esposito, Shenjiang Yu, Daisy Richardson, Valentyn Antochshuk, Mohammed Shameem

Journal of Pharmaceutical Sciences · 2015 · 32 citations · 23 references

DOI

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References

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[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

C. Nick Pace · Methods in enzymology on CD-ROM/Methods in enzymology · 1986 · 2.3K citations

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Denaturant <i>m</i> values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding

Jeffrey K. Myers, C. Nick Pace, J. Martin Scholtz · Protein Science · 1995 · 1.7K citations · Full text

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Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl .alpha.-chymotrypsin using different denaturants

Marcelo M. Santoro, D. Wayne Bolen · Biochemistry · 1988 · 1.6K citations

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Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

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Thermofluor-based high-throughput stability optimization of proteins for structural studies

U.B. Ericsson, B.M. Hallberg, George T. DeTitta et al. · Analytical Biochemistry · 2006 · 843 citations

, , +10