Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Katarina Trajković, Chieh Hsu, Salvatore Chiantia et al. · Science · 2008 · 3.5K citations · Full text

Molecular Biology, Extracellular Microvesicles, Cytoskeleton +19

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Mehrdad Matloubian, Charles G. Lo, Guy Cinamon et al. · Nature · 2004 · 2.5K citations

Thymus Biology, Autoimmune Disease, Immunology +11

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Babette Weksler, Eva-Anne Subileau, Nicolas Perrière et al. · The FASEB Journal · 2005 · 1.3K citations

T-regulatory Cell, Immunology, Blood Cell +23

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

Stefan Schütze, Karin Potthoff, Thomas Machleidt et al. · Cell · 1992 · 1.1K citations

Inflammation, Signal Transduction, Apoptosis +8

Acid sphingomyelinase activity triggers microparticle release from glial cells

Fabio Bianco, Cristiana Perrotta, Luisa Novellino et al. · The EMBO Journal · 2009 · 574 citations · Full text

Glial Cells, Medicine, Cell Biology +4