Concepedia

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

Rui Xu, Anna L. Banka, James F. Blake, Ian S. Mitchell, Eli M. Wallace, Josef R. Bencsik, Nicholas C. Kallan, Keith L. Spencer, Susan L. Gloor, Matthew Martinson,

Bioorganic & Medicinal Chemistry Letters · 2011 · 10 citations · 14 references

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14

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

, , +16

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics · 1997 · 2.8K citations

, , +11

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification <sup>1</sup>

Steven K. Hanks, Tony Hunter · The FASEB Journal · 1995 · 2.3K citations

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Molecular cloning, expression and characterization of the human serine/threonine kinase Akt‐3

Stefan Masure, Burkhard Haefner, Jan‐Jaap Wesselink et al. · European Journal of Biochemistry · 1999 · 159 citations · Full text

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