Organic Letters · 2002 · 71 citations · 18 references
PharmacyBiochemistryMedicinal ChemistryBiocatalysisCatalysisCombinatorial ChemistryCatalytic MechanismsEnzyme-substrate RecognitionLigand BindingProtein-ligand BindingProtein-ligand InteractionsProtein-ligand RecognitionCatalytic EfficiencyLigand DesignProtein Substrate SpecificityProtein-binding LibrariesSubstrate Attachment
A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text]
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