Concepedia

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

Mihai Azimioara, Phil B. Alper, Christopher Cow, Daniel Mutnick, V. I. Nikulin, G. Lelais, John S. Mecom, Matthew McNeill, Pierre‐Yves Michellys, Zhiliang Wang,

Bioorganic & Medicinal Chemistry Letters · 2014 · 14 citations · 6 references

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6

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

Hilary A. Overton, Adam J. Babbs, S. M. Doel et al. · Cell Metabolism · 2006 · 648 citations · Full text

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Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Graeme Semple, Beatriz Fioravanti, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2008 · 142 citations · Full text

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Agonists at GPR119 mediate secretion of GLP‐1 from mouse enteroendocrine cells through glucose‐independent pathways

Wang Cf, M. Jerry Wright, Shiyao Xu et al. · British Journal of Pharmacology · 2011 · 84 citations · Full text

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The first pharmacophore model for potent G protein-coupled receptor 119 agonist

Xiaoyun Zhu, Dandan Huang, Xiaobu Lan et al. · European Journal of Medicinal Chemistry · 2011 · 26 citations

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