G. Lelais - Concepedia

Author

G. Lelais

Genomics Institute of the Novartis Research Foundation ORCID

Also Known As

G. Lelais, Gerald Lelais, Gérald Lelais, Lelais, G., Lelais, Gérald

Publications

2.7K

Citations

H-Index

Concepts

All Affiliations

Genomics Institute of the Novartis Research Foundation ETH Zurich

About

G. Lelais is an author at Genomics Institute of the Novartis Research Foundation specializing in medicine, natural sciences, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	11	12	1.4K
2	Natural Sciences	9	9	356
3	Biochemistry	9	9	356
4	Engineering	4	4	748
5	Biomolecular Engineering	4	4	176

G. Lelais

Publications

2.2K

Citations

H-Index

Page 1

	Year	Citations
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors Yong Jia, Cai‐Hong Yun, Eunyoung Park, Nature Molecular PharmacologyMedicinePharmacologyMutant-selective Allosteric InhibitorsNovel Therapy	2016	851
Modern strategies in organic catalysis: The advent and development of iminium activation G. Lelais, David W. C. MacMillan Aldrichimica acta Chemical EngineeringOrganic CatalysisEngineeringModern StrategiesIminium Activation	2006	631
EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor Yong Jia, Jose Juarez, Jie Li, Cancer Research	2016	120
Discovery of (<i>R</i>,<i>E</i>)-<i>N</i>-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers G. Lelais, Robert Epple, Thomas H. Marsilje, Journal of Medicinal Chemistry Tumor BiologyGood Wt-egfr SelectivityNew TherapiesEgfr MutantsAnti-cancer Agent	2016	94
Electrophilic <i>S</i>‐Trifluoromethylation of Cysteine Side Chains in <i>α</i>‐ and <i>β</i>‐Peptides: Isolation of Trifluoro‐methylated <i>Sandostatin</i><sup>®</sup> (Octreotide) Derivatives Stefania Capone, Iris Kieltsch, Oliver Flögel, Helvetica Chimica Acta Bioorganic ChemistryPeptide EngineeringMolecular BiologyOrganic ChemistryPeptide Science	2008	90
Synthesis, CD Spectra, and Enzymatic Stability of <i>β</i><sup>2</sup>‐Oligoazapeptides Prepared from (<i>S</i>)‐2‐Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu G. Lelais, Dieter Seebàch Helvetica Chimica Acta Combinatorial Chemistry‐Peptide AnalogsOrganic ChemistryPeptide SciencePeptide Therapeutics	2003	80
Development of a virtual reality platform for effective communication of structural data in drug discovery Laura J. Kingsley, Vincent Brunet, G. Lelais, Journal of Molecular Graphics and Modelling Detailed VisualizationStructural KnowledgeEngineeringDrug TargetHit Identification	2019	71
Enantioselective Preparation of 2‐Aminomethyl Carboxylic Acid Derivatives: Solving the <i>β</i><sup>2</sup>‐Amino Acid Problem with the Chiral Auxiliary 4‐Isopropyl‐5,5‐diphenyloxazolidin‐2‐one (DIOZ). Preliminary Communication Dieter Seebàch, Laurent Schaeffer, F. Gessier, Helvetica Chimica Acta Organic ChemistryPeptide ScienceChemistryEnantioselective PreparationDioz Derivatives	2003	50
Determination of zinc to beta‐peptide binding constants with electrospray ionization mass spectrometry Arno Wortmann, Francesco Rossi, G. Lelais, Journal of Mass Spectrometry	2005	47
β-Peptidic Secondary Structures Fortified and Enforced by Zn2+ Complexation – On the Way toβ-Peptidic Zinc Fingers? G. Lelais, Dieter Seebàch, Bernhard Jaun, Helvetica Chimica Acta Zn2+ Complexation –Protein AssemblyPeptide EngineeringMolecular BiologyPeptide Science	2006	34

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