G. Lelais

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 851 citations · Full text

Molecular Pharmacology, Medicine, Pharmacology +4

Modern strategies in organic catalysis: The advent and development of iminium activation

G. Lelais, David W. C. MacMillan · Aldrichimica acta · 2006 · 631 citations

Chemical Engineering, Organic Catalysis, Engineering +9

EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Yong Jia, Jose Juarez, Jie Li et al. · Cancer Research · 2016 · 120 citations · Full text

Discovery of (<i>R</i>,<i>E</i>)-<i>N</i>-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

G. Lelais, Robert Epple, Thomas H. Marsilje et al. · Journal of Medicinal Chemistry · 2016 · 94 citations · Full text

Tumor Biology, Good Wt-egfr Selectivity, New Therapies +17

Electrophilic <i>S</i>‐Trifluoromethylation of Cysteine Side Chains in <i>α</i>‐ and <i>β</i>‐Peptides: Isolation of Trifluoro‐methylated <i>Sandostatin</i>^® (Octreotide) Derivatives

Stefania Capone, Iris Kieltsch, Oliver Flögel et al. · Helvetica Chimica Acta · 2008 · 90 citations

Bioorganic Chemistry, Peptide Engineering, Molecular Biology +19