Jose Juarez

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 879 citations · Full text

Medicine, Oncology, Pharmacology +11

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

Rebecca J. Gum, Ernst Lengyel, Jose Juarez et al. · Journal of Biological Chemistry · 1996 · 348 citations · Full text

Medicine, Cancer Biology, Molecular Biology +17

Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity

Jose Juarez, Gary L. Clayman, Motowo Nakajima et al. · International Journal of Cancer · 1993 · 121 citations

Medicine, Cancer Biology, Cell Biology +17

EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Yong Jia, Jose Juarez, Jie Li et al. · Cancer Research · 2016 · 121 citations · Full text

Medicine, Oncology, Pharmacology +14

Discovery of (<i>R</i>,<i>E</i>)-<i>N</i>-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

G. Lelais, Robert Epple, Thomas H. Marsilje et al. · Journal of Medicinal Chemistry · 2016 · 95 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14