Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid β precursor protein

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature · 1987 · 4.6K citations

Alzheimer's Disease, Protein Folding, Cell-surface Receptor +7

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.2K citations

Synaptic Plasticity, Alzheimer's Disease, Molecular Neuroscience +7

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4K citations

Soluble Amyloid Oligomers, Alzheimer's Disease, Biochemistry +12

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Mary P. Lambert, Avlin Barlow, Brett A. Chromy et al. · Proceedings of the National Academy of Sciences · 1998 · 3.5K citations · Full text

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Toshiyuki Nakagawa, Hong Zhu, Nobuhiro Morishima et al. · Nature · 2000 · 3.2K citations

Apoptosis, Cell Death, Degenerative Pathology +5