Concepedia

Protofibril Formation

Protofibril Formation is a biochemical process in amyloidogenesis wherein soluble protein monomers undergo partial structural rearrangement and associate into transient, soluble, linear oligomeric assemblies that precede the formation of mature amyloid fibrils.

532

Publications

52.8K

Citations

2.2K

Authors

679

Institutions

Publications per year

2017–2026

111

Parents

Publications

532

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Kelly A. Conway, James D. Harper, Peter T. Lansbury · Nature Medicine · 1998 · 1.5K citations

, , +16

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

Karie N. Dahlgren, Arlene M. Manelli, W. Blaine Stine et al. · Journal of Biological Chemistry · 2002 · 1.4K citations · Full text

, , +17

Role of <i>Escherichia coli</i> Curli Operons in Directing Amyloid Fiber Formation

Matthew R. Chapman, Lloyd S. Robinson, Jerome S. Pinkner et al. · Science · 2002 · 1.3K citations · Full text

, , +17

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

Camilla Nilsberth, Anita Westlind‐Danielsson, Christopher B. Eckman et al. · Nature Neuroscience · 2001 · 1.2K citations

, , +14

Designing conditions for <i>in vitro</i> formation of amyloid protofilaments and fibrils

Fabrizio Chiti, Paul Webster, Niccolò Taddei et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations · Full text

, , +17

1–5 of 532

Authors

2.2K

  1. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    15 publications · 3.4K citations

    15

    h-index

  2. GW
    Guanghong Wei

    Fudan University, China

    12 publications · 682 citations

    12

    h-index

  3. LL
    Lars Lannfelt

    Uppsala University, Sweden

    10 publications · 2.1K citations

    10

    h-index

  4. PT
    Peter T. Lansbury

    Harvard University, United States

    10 publications · 5K citations

    10

    h-index

  5. MF
    Marcus Fändrich

    Universität Ulm, Germany

    10 publications · 981 citations

    10

    h-index

1–5 of 2.2K

Institutions

679

  1. University of Cambridge

    Cambridge, United Kingdom

    18 h-index

    62 publications

    12.2K citations

  2. Brigham and Women's Hospital

    Boston, United States

    17 h-index

    55 publications

    21.7K citations

  3. Harvard University

    Cambridge, United States

    17 h-index

    68 publications

    27.8K citations

  4. Uppsala University

    Uppsala, Sweden

    13 h-index

    67 publications

    6.8K citations

  5. Fudan University

    Shanghai, China

    13 h-index

    37 publications

    2.5K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    48 publications

    2.8K citations

  7. University of Florence

    Florence, Italy

    11 h-index

    43 publications

    9.7K citations

  8. University of Pennsylvania

    Philadelphia, United States

    10 h-index

    26 publications

    2K citations

1–8 of 679

Venues

  1. Journal of Biological Chemistry

    JBC · 41 publications · 6.5K citations

    35

    h-index

  2. Journal of Molecular Biology

    JMB · 34 publications · 3.6K citations

    31

    h-index

  3. Biochemistry

    35 publications · 5.2K citations

    29

    h-index

  4. Biophysical Journal

    29 publications · 3.4K citations

    24

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 4.3K citations

    22

    h-index

1–5