Concepedia

Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity

Hiroyuki Nakamura, Yuka Yasui, Hyun Seung Ban

Journal of Organometallic Chemistry · 2013 · 20 citations · 17 references

DOI

Concepts

References

17

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Michael Ohh, Cheol Won Park, Mircea Ivan et al. · Nature Cell Biology · 2000 · 1.6K citations

, , +12

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

Fang Yu, Sarah B. White, Quan Zhao et al. · Proceedings of the National Academy of Sciences · 2001 · 793 citations · Full text

, , +14