Concepedia

N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation

Petr Chytil, Tomáš Etrych, Vladimír Šubr, Karel Ulbrich

European Journal of Pharmaceutical Sciences · 2010 · 135 citations · 33 references

Concepts

Medicinal ChemistryDrug TargetingMethacrylamide-based Polymer ConjugatesPassive TumourMedicinePolymer-drug ConjugateBioconjugationRaft PolymerisationTumor TargetingAnti-cancer AgentPharmacologyRadiation OncologyTumor Biology

References

33

Tissue sulfhydryl groups

George L. Ellman · Archives of Biochemistry and Biophysics · 1959 · 25.9K citations

Biochemistry, Glycobiology, Tissue Physiology +3

Living Radical Polymerization by the RAFT Process

Graeme Moad, Ezio Rizzardo, San H. Thang · Australian Journal of Chemistry · 2005 · 2.2K citations

Radical Polymerization, Engineering, Macromolecular Engineering +13

Tumoritropic and lymphotropic principles of macromolecular drugs.

Hiroshi Maeda, Yasuhiro Matsumura · PubMed · 1989 · 580 citations

Medicinal Chemistry, Mw 16, Drug Targeting +13

Reversible Addition−Fragmentation Chain Transfer Polymerization: End Group Modification for Functionalized Polymers and Chain Transfer Agent Recovery

Sébastien Perrier, Pittaya Takolpuckdee, Craig A. Mars · Macromolecules · 2005 · 476 citations

Organic Compounds, Functionalized Polymers, Engineering +14

A novel synthesis of functional dithioesters, dithiocarbamates, xanthates and trithiocarbonates

San H. Thang, Yu Chong, Roshan T. A. Mayadunne et al. · Tetrahedron Letters · 1999 · 452 citations

Engineering, Functional Dithioesters, Organic Chemistry +4