Concepedia

Ph-dependent Activation

pH-Dependent Activation is a prodrug activation mechanism in which the conversion of an inactive precursor into its active pharmacological form is selectively triggered by changes in environmental pH, exploiting acidic or basic conditions in specific physiological or pathological compartments.

366

Publications

22.9K

Citations

1.6K

Authors

497

Institutions

Publications per year

2017–2026

48

Parents

Publications

366

Gamma Aminobutyric Acid (GABA) and Plant Responses to Stress

Alan M. Kinnersley, Frank J. Turano · Critical Reviews in Plant Sciences · 2000 · 672 citations

, , +17

Gamma Aminobutyric Acid (GABA) and Plant Responses to Stress

Alan M. Kinnersley · Critical Reviews in Plant Sciences · 2000 · 566 citations

, , +17

Akt activation by growth factors is a multiple-step process: the role of the PH domain

Alfonso Bellacosa, Tung O. Chan, Naheed N. Ahmed et al. · Oncogene · 1998 · 542 citations

, , +15

Cell-Specific and pH-Activatable Rubyrin-Loaded Nanoparticles for Highly Selective Near-Infrared Photodynamic Therapy against Cancer

Jiangwei Tian, Lin Ding, Haijun Xu et al. · Journal of the American Chemical Society · 2013 · 412 citations

, , +17

Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β

R.M. Kottmann, Ajit A. Kulkarni, Katie Smolnycki et al. · American Journal of Respiratory and Critical Care Medicine · 2012 · 408 citations

, , +13

1–5 of 366

Authors

1.6K

  1. KU
    Karel Ulbrich

    Czech Academy of Sciences, Institute of Macromolecular Chemistry, Czechia

    5 publications · 373 citations

    5

    h-index

  2. CJ
    Charles J. Russell

    St. Jude Children's Research Hospital, United States

    5 publications · 511 citations

    5

    h-index

  3. HZ
    Hassan Zaraket

    American University of Beirut, Lebanon

    3 publications · 333 citations

    3

    h-index

  4. KS
    Klaus Seuwen

    Novartis (Switzerland), Switzerland

    3 publications · 131 citations

    3

    h-index

  5. TE
    Tomáš Etrych

    Czech Academy of Sciences, Institute of Macromolecular Chemistry, Czechia

    3 publications · 314 citations

    3

    h-index

1–5 of 1.6K

Institutions

497

  1. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    25 publications

    1.3K citations

  2. Johns Hopkins University

    Baltimore, United States

    6 h-index

    14 publications

    1.1K citations

  3. University of Tennessee Health Science Center

    Memphis, United States

    6 h-index

    12 publications

    1.2K citations

  4. Yale University

    New Haven, United States

    6 h-index

    19 publications

    989 citations

  5. Northwestern University

    Evanston, United States

    5 h-index

    12 publications

    1.4K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    8 publications

    659 citations

  7. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    17 publications

    545 citations

  8. St. Jude Children's Research Hospital

    Memphis, United States

    5 h-index

    37 publications

    3.8K citations

1–8 of 497

Venues

  1. Journal of Biological Chemistry

    JBC · 34 publications · 2.4K citations

    25

    h-index

  2. Biochemistry

    12 publications · 694 citations

    12

    h-index

  3. Journal of Virology

    JVI · 12 publications · 1.3K citations

    12

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.1K citations

    12

    h-index

  5. Journal of the American Chemical Society

    JACS · 12 publications · 1.3K citations

    12

    h-index

1–5